Dengue-1 envelope protein domain III along with PELC and CpG oligodeoxynucleotides synergistically enhances immune responses.

• Main Authors: Chen-Yi Chiang (Author), Ming-Hsi Huang (Author), Chun-Hsiang Hsieh (Author), Mei-Yu Chen (Author), Hsueh-Hung Liu (Author), Jy-Ping Tsai (Author), Yi-Shiuan Li (Author), Ching-Yun Chang (Author), Shih-Jen Liu (Author), Pele Chong (Author), Chih-Hsiang Leng (Author), Hsin-Wei Chen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The major weaknesses of subunit vaccines are their low immunogenicity and poor efficacy. Adjuvants can help to overcome some of these inherent defects with subunit vaccines. Here, we evaluated the efficacy of the newly developed water-in-oil-in-water multiphase emulsion system, termed PELC, in poten...