Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2

• Main Authors: Baolin Xu (Author), Andrea Janicova (Author), Jan Tilmann Vollrath (Author), Philipp Störmann (Author), Lukas Martin (Author), Ingo Marzi (Author), Sebastian Wutzler (Author), Frank Hildebrand (Author), Sabrina Ehnert (Author), Borna Relja (Author)
• Format: Book
• Published: BMC, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Club Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-inflammatory and immunosuppressive effects, however, its influence on PMN...