Discovery of a Novel Natural Allosteric Inhibitor That Targets NDM-1 Against Escherichia coli

• Main Authors: Yanan Yang (Author), Yan Guo (Author), Yonglin Zhou (Author), Yawen Gao (Author), Xiyan Wang (Author), Jianfeng Wang (Author), Xiaodi Niu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

At present, the resistance of New Delhi metallo-β-lactamase-1 (NDM-1) to carbapenems and cephalosporins, one of the mechanisms of bacterial resistance against β-lactam antibiotics, poses a threat to human health. In this work, based on the virtual ligand screen method, we found that carnosic acid1 (...