Discovery of a Novel Natural Allosteric Inhibitor That Targets NDM-1 Against Escherichia coli

• Prif Awduron: Yanan Yang (Awdur), Yan Guo (Awdur), Yonglin Zhou (Awdur), Yawen Gao (Awdur), Xiyan Wang (Awdur), Jianfeng Wang (Awdur), Xiaodi Niu (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

At present, the resistance of New Delhi metallo-β-lactamase-1 (NDM-1) to carbapenems and cephalosporins, one of the mechanisms of bacterial resistance against β-lactam antibiotics, poses a threat to human health. In this work, based on the virtual ligand screen method, we found that carnosic acid1 (...