Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide

• Main Authors: Cristina Matteo (Author), Isabella Orienti (Author), Adriana Eramo (Author), Ann Zeuner (Author), Mariella Ferrari (Author), Alice Passoni (Author), Renzo Bagnati (Author), Marianna Ponzo (Author), Ezia Bello (Author), Massimo Zucchetti (Author), Roberta Frapolli (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumor distribution of fenretinide, a synthetic retinoid chemically related to all-trans-retinoic acid, after administration of a novel oral nanoformulation of fenretinide, called bionanofenretinide (...