Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

• Main Authors: Daniel Morales-Cano (Author), Bianca Barreira (Author), Beatriz De Olaiz Navarro (Author), María Callejo (Author), Gema Mondejar-Parreño (Author), Sergio Esquivel-Ruiz (Author), Jose A. Lorente (Author), Laura Moreno (Author), Joan A. Barberá (Author), Ángel Cogolludo (Author), Francisco Perez-Vizcaino (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli,...