Mechanism of Na+/Ca2+ Exchanger Activation by Hydrogen Peroxide in Guinea-Pig Ventricular Myocytes

• Главные авторы: Masamitsu Hinata (Автор), Isao Matsuoka (Автор), Takahiro Iwamoto (Автор), Yasuhide Watanabe (Автор), Junko Kimura (Автор)
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• Опубликовано: Elsevier, 2007-01-01T00:00:00Z.
• Предметы: article
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Using the whole-cell voltage clamp, we examined the mechanism of activation of the Na+/Ca2+ exchanger (NCX) by hydrogen peroxide (H2O2) in isolated guinea-pig cardiac ventricular myocytes. Exposure to H2O2 increased the NCX current. The effect was inhibited by cariporide, an inhibitor of the Na+/H+...