Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection.

• Main Authors: Melissa C Sanchez (Author), Katina V Krasnec (Author), Amalia S Parra (Author), Christian von Cabanlong (Author), Geoffrey N Gobert (Author), Boris Umylny (Author), Pauline M Cupit (Author), Charles Cunningham (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis is a chronic parasitic disease caused by sexually dimorphic blood flukes of the genus Schistosoma. Praziquantel (PZQ) is the only drug widely available to treat the disease but does not kill juvenile parasites. Here we report the use of next generation sequencing to study the transcr...