Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion

Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2+) from cytosol into the lumen of the endoplasmic...

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Main Authors: Wen Zhang (Author), Fanghua Ye (Author), Nan Pang (Author), Miriam Kessi (Author), Juan Xiong (Author), Shimeng Chen (Author), Jing Peng (Author), Li Yang (Author), Fei Yin (Author)
Format: Book
Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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