Oral delivery of the Sj23LHD-GST antigen by Salmonella typhimurium type III secretion system protects against Schistosoma japonicum infection in mice.

• Principais autores: Guo Chen (Autor), Yang Dai (Autor), Jianxiang Chen (Autor), Xiaoting Wang (Autor), Bo Tang (Autor), Yinchang Zhu (Autor), Zichun Hua (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2011-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BACKGROUND: Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacte...