Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study

• Main Authors: Khlood Mohammad Aldossary (Author), Lashin Saad Ali (Author), Mahmoud S. Abdallah (Author), Mostafa M. Bahaa (Author), Thanaa A. Elmasry (Author), Eman I. Elberri (Author), Fedaa A. Kotkata (Author), Ramy M. El Sabaa (Author), Yasmine M. Elmorsi (Author), Mostafa M. Kamel (Author), Walaa A. Negm (Author), Aya Ibrahim Elberri (Author), Amir O. Hamouda (Author), Hayam Ali AlRasheed (Author), Muhammed M. Salahuddin (Author), Mohamed Yasser (Author), Manal A. Hamouda (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundNeuroinflammation pathways have been associated with the development of major depressive disorders (MDD). The anti-inflammatory characteristics of statins have been demonstrated to have significance in the pathophysiology of depression.AimTo investigate the mechanistic pathways of high dos...