Beta-hydroxybutyrate dampens adipose progenitors' profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms

• Main Authors: Simon Lecoutre (Author), Fatiha Merabtene (Author), Elie-Julien El Hachem (Author), Camille Gamblin (Author), Christine Rouault (Author), Nataliya Sokolovska (Author), Hedi Soula (Author), Wi S. Lai (Author), Perry J. Blackshear (Author), Karine Clément (Author), Isabelle Dugail (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Purpose: Adipose tissue contains progenitor cells that contribute to beneficial tissue expansion when needed by de novo adipocyte formation (classical white or beige fat cells with thermogenic potential). However, in chronic obesity, they can exhibit an activated pro-fibrotic, extracellul...