Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides

Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools. PS-ASOs can enter cells via endocytic pathways and escape from membrane-enclosed endocytic organelles to r...

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Main Authors: Shiyu Wang (Author), Nickolas Allen (Author), Xue-hai Liang (Author), Stanley T. Crooke (Author)
Format: Book
Published: Elsevier, 2018-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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