Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

• Main Authors: Adolfo Marican (Author), Fabián Avila-Salas (Author), Oscar Valdés (Author), Sergio Wehinger (Author), Jorge Villaseñor (Author), Natalia Fuentealba (Author), Mauricio Arenas-Salinas (Author), Yerko Argandoña (Author), Verónica Carrasco-Sánchez (Author), Esteban F. Durán-Lara (Author)
• Format: Book
• Published: MDPI AG, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, th...