Differential expression of the IRF6 gene in the signs of Van der Woude Syndrome: Are distinct genetic modifiers operating?

• Main Authors: Rosany de Oliveira Lisboa (Author), Cláudia Maria da Rocha Martins (Author), Maria Elisabete Silva Santos (Author), Danilo Leôncio Aguiar Pereira (Author), Flávia Martinez de Carvalho (Author), Ieda Maria Orioli (Author), João Farias Guerreiro (Author), Alexandre Rezende Vieira (Author), Luiz Carlos Santana- (Author)
• Format: Book
• Published: University Library System, University of Pittsburgh, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The purpose of this study was to report a new variant in the Interferon Regulatory Factor 6 gene (IRF6) and to determine phenotype-genotype correlations in a family segregating Van der Woude syndrome. Methods: A five-generation family of 80 individuals segregating VWS was investigated usi...