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First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation

Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitin-proteasome system (UPS), thereby selectively reducing the target protein level by the ubiquitin-proteasome pa...

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Main Authors: Zhenzhen Li (Author), Yuxing Lin (Author), Hui Song (Author), Xiaojun Qin (Author), Zhongxia Yu (Author), Zheng Zhang (Author), Gaopan Dong (Author), Xiang Li (Author), Xiaodong Shi (Author), Lupei Du (Author), Wei Zhao (Author), Minyong Li (Author)
Format: Book
Published: Elsevier, 2020-09-01T00:00:00Z.
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