Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

• Hoofdauteurs: Esteban Cruz (Auteur), Vicki Sifniotis (Auteur), Zeynep Sumer-Bayraktar (Auteur), Mouhamad Reslan (Auteur), Lorna Wilkinson-White (Auteur), Stuart Cordwell (Auteur), Veysel Kayser (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair...