Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

• Main Authors: Esteban Cruz (Author), Vicki Sifniotis (Author), Zeynep Sumer-Bayraktar (Author), Mouhamad Reslan (Author), Lorna Wilkinson-White (Author), Stuart Cordwell (Author), Veysel Kayser (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-10-01T00:00:00Z.
• Fag: article
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Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair...