Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair...

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Main Authors: Esteban Cruz (Author), Vicki Sifniotis (Author), Zeynep Sumer-Bayraktar (Author), Mouhamad Reslan (Author), Lorna Wilkinson-White (Author), Stuart Cordwell (Author), Veysel Kayser (Author)
Format: Book
Published: MDPI AG, 2021-10-01T00:00:00Z.
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3rd Floor Main Library

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