Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

• Main Authors: Esteban Cruz (Author), Vicki Sifniotis (Author), Zeynep Sumer-Bayraktar (Author), Mouhamad Reslan (Author), Lorna Wilkinson-White (Author), Stuart Cordwell (Author), Veysel Kayser (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair...