Case Report: Atypical HUS Presenting With Acute Rhabdomyolysis Highlights the Need for Individualized Eculizumab Dosing

• Main Authors: Stefanie W. Benoit (Author), Tsuyoshi Fukuda (Author), Katherine VandenHeuvel (Author), David Witte (Author), Christine Fuller (Author), Jennifer Willis (Author), Bradley P. Dixon (Author), Keri A. Drake (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundAtypical hemolytic uremic syndrome (aHUS) is an ultra-rare orphan disease caused by dysregulated complement activation resulting in thrombotic microangiopathy. Although complement-mediated endothelial injury predominantly affects the renal microvasculature, extra-renal manifestations are p...