Role of microglia in the dissemination of Zika virus from mother to fetal brain.

• Main Authors: Pei Xu (Author), Chao Shan (Author), Tiffany J Dunn (Author), Xuping Xie (Author), Hongjie Xia (Author), Junling Gao (Author), Javier Allende Labastida (Author), Jing Zou (Author), Paula P Villarreal (Author), Caitlin R Schlagal (Author), Yongjia Yu (Author), Gracie Vargas (Author), Shannan L Rossi (Author), Nikolaos Vasilakis (Author), Pei-Yong Shi (Author), Scott C Weaver (Author), Ping Wu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model of ZIKV vertical t...