Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms

• Main Authors: Li Guan (Author), Ya-Hui Liao (Author), Meng-Xue Cao (Author), Li-Yun Liu (Author), Hai-Tao Xue (Author), Hong-Rui Zhu (Author), Chang-Hao Bian (Author), Fan Yang (Author), Hou-Wen Lin (Author), Hong-Ze Liao (Author), Fan Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance is a substantial obstacle in treating non-small cell lung cancer (NSCLC) with therapies like cisplatin (DDP)-based adjuvant chemotherapy and EGFR-tyrosine kinase inhibitors (TKIs). Aaptamine-7 (AP-7), a benzonaphthyridine alkaloid extracted from Aaptos aaptos sponge, has been sh...