Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms

• Автори: Li Guan (Автор), Ya-Hui Liao (Автор), Meng-Xue Cao (Автор), Li-Yun Liu (Автор), Hai-Tao Xue (Автор), Hong-Rui Zhu (Автор), Chang-Hao Bian (Автор), Fan Yang (Автор), Hou-Wen Lin (Автор), Hong-Ze Liao (Автор), Fan Sun (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Multidrug resistance is a substantial obstacle in treating non-small cell lung cancer (NSCLC) with therapies like cisplatin (DDP)-based adjuvant chemotherapy and EGFR-tyrosine kinase inhibitors (TKIs). Aaptamine-7 (AP-7), a benzonaphthyridine alkaloid extracted from Aaptos aaptos sponge, has been sh...