Phase I clinical trial of NH130 and the prediction of its pharmacokinetics using physiologically based pharmacokinetic modeling

BackgroundParkinson's disease psychosis (PDP) is a common and distressing complication of Parkinson's disease (PD), characterized by hallucinations and delusions. This research aimed to assess the pharmacokinetics and safety of NH130, a selective serotonin 5-HT2A inverse agonist, as a pote...

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Main Authors: Kun Zhang (Author), Shanshan Zhao (Author), Jialin Du (Author), Lan Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
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