Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells

• Main Authors: Huagang Sheng (Author), Yuanyuan Zhang (Author), Jijuan Nai (Author), Shaohua Wang (Author), Mengmeng Dai (Author), Guitao Lin (Author), Liqiao Zhu (Author), Qiang Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Oridonin (ORI) has obvious anticancer effects, but its solubility is poor. Nanocrystal (NC) is a novel nano-drug delivery system for increasing bioavailability for ORI. However, the endocytosis and transcytosis behaviours of oridonin nanocrystals (ORI-NCs) through epithelial membrane are sti...