Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells

• Glavni autori: Huagang Sheng (Autor), Yuanyuan Zhang (Autor), Jijuan Nai (Autor), Shaohua Wang (Autor), Mengmeng Dai (Autor), Guitao Lin (Autor), Liqiao Zhu (Autor), Qiang Zhang (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Context Oridonin (ORI) has obvious anticancer effects, but its solubility is poor. Nanocrystal (NC) is a novel nano-drug delivery system for increasing bioavailability for ORI. However, the endocytosis and transcytosis behaviours of oridonin nanocrystals (ORI-NCs) through epithelial membrane are sti...