Dosing-time-dependent effect of rivaroxaban on coagulation activity in rats

• Main Authors: Yuki Fujiwara (Author), Hitoshi Ando (Author), Kentaro Ushijima (Author), Michiko Horiguchi (Author), Chikamasa Yamashita (Author), Akio Fujimura (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The anticoagulant effect of rivaroxaban, a direct inhibitor of activated factor X (FX), might be influenced by its dosing time because the activity of the coagulofibrinolytic system exhibits daily rhythmicity. In rats, FX activity follows a 24-h rhythm with a peak in the middle of the light phase an...