Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells

• Main Authors: Rana M. Abdelnaby (Author), Heba S. Rateb (Author), Omaima Ali (Author), Ahmed S. Saad (Author), Rania I. Nadeem (Author), Sahar M. Abou-Seri (Author), Kamilia M. Amin (Author), Nancy S. Younis (Author), Rasha Abdelhady (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Breast cancer is the most common malignancy worldwide; therefore, the development of new anticancer agents is essential for improved tumor control. By adopting the pharmacophore hybridization approach, two series of 7-hydroxyl-4-methylcoumarin hybridized with thiosemicarbazone (<b>V-VI</b&g...