Targeting active RAS with molecular glue
Activating mutations in RAS genes, notably KRASG12C, are pervasive in numerous cancers, presenting formidable challenges to therapy due to their elusive druggability. The landmark discovery of KRASG12C allosteric inhibitors marked a transformative milestone in cancer treatment, resulting in the appr...
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Elsevier,
2024-12-01T00:00:00Z.
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