Abscopal Effects in Radio-Immunotherapy-Response Analysis of Metastatic Cancer Patients With Progressive Disease Under Anti-PD-1 Immune Checkpoint Inhibition

• Main Authors: Maike Trommer (Author), Sin Yuin Yeo (Author), Thorsten Persigehl (Author), Anne Bunck (Author), Holger Grüll (Author), Max Schlaak (Author), Sebastian Theurich (Author), Michael von Bergwelt-Baildon (Author), Janis Morgenthaler (Author), Jan M. Herter (Author), Eren Celik (Author), Simone Marnitz (Author), Christian Baues (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint inhibition (ICI) targeting the programmed death receptor 1 (PD-1) has shown promising results in the fight against cancer. Systemic anti-tumor reactions due to radiation therapy (RT) can lead to regression of non-irradiated lesions (NiLs), termed "abscopal effect" (AbE)....