C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells

• Główni autorzy: Eileen Lynch (Autor), Theran Semrad (Autor), Vincent S. Belsito (Autor), Claire FitzGibbons (Autor), Megan Reilly (Autor), Koji Hayakawa (Autor), Masatoshi Suzuki (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2019-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease with no cure and limited treatment options. Patients experience a gradual paralysis leading to death from respiratory complications on average only 2-5 years after diagnosis. There is increasing evidence that skeletal muscle i...