C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells

• Main Authors: Eileen Lynch (Author), Theran Semrad (Author), Vincent S. Belsito (Author), Claire FitzGibbons (Author), Megan Reilly (Author), Koji Hayakawa (Author), Masatoshi Suzuki (Author)
• Format: Book
• Published: The Company of Biologists, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease with no cure and limited treatment options. Patients experience a gradual paralysis leading to death from respiratory complications on average only 2-5 years after diagnosis. There is increasing evidence that skeletal muscle i...