Pharmacokinetic Imaging Using ^99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

• Main Authors: Solène Marie (Author), Irene Hernández-Lozano (Author), Marc Le Vée (Author), Louise Breuil (Author), Wadad Saba (Author), Maud Goislard (Author), Sébastien Goutal (Author), Charles Truillet (Author), Oliver Langer (Author), Olivier Fardel (Author), Nicolas Tournier (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. ^99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. <sup>...