Pharmacokinetic Imaging Using ^99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

• Egile Nagusiak: Solène Marie (Egilea), Irene Hernández-Lozano (Egilea), Marc Le Vée (Egilea), Louise Breuil (Egilea), Wadad Saba (Egilea), Maud Goislard (Egilea), Sébastien Goutal (Egilea), Charles Truillet (Egilea), Oliver Langer (Egilea), Olivier Fardel (Egilea), Nicolas Tournier (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. ^99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. <sup>...