Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing

• Main Authors: Zhiru Wang (Author), Wenting Kang (Author), Ouwen Li (Author), Fengyu Qi (Author), Junwei Wang (Author), Yinghua You (Author), Pengxing He (Author), Zhenhe Suo (Author), Yichao Zheng (Author), Hong-Min Liu (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for treating melanoma, gastric cancer (GC) and bladder cancer with clinical benefit. Nevertheless, many patients failed to respond to anti-PD-1/PD-L1 treatment, so it...