HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice

• Main Authors: Young-Eun Kim (Author), Minji Lee (Author), Hyejung Gu (Author), Jeongwoo Kim (Author), Seongju Jeong (Author), Sujin Yeo (Author), You Jeong Lee (Author), Sin-Hyeog Im (Author), Young-Chul Sung (Author), Hak Jae Kim (Author), Irving L. Weissman (Author), G-One Ahn (Author)
• Format: Book
• Published: The Company of Biologists, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease, in which the intestinal epithelium loses its barrier function. Given the existence of the oxygen gradient in the intestinal epithelium and that inflammation further contributes to the tissue hypoxia, we investigated the role of hypo...