Growth Hormone Signaling Pathway Leading to the Induction of DNA Synthesis and Proliferation in Primary Cultured Hepatocytes of Adult Rats

• Main Authors: Mitsutoshi Kimura (Author), Kazuki Kurihara (Author), Hajime Moteki (Author), Masahiko Ogihara (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Background: We investigated the signal transduction pathway associated with growth hormone (GH)-stimulated DNA synthesis and proliferation in primary cultured hepatocytes. Methods: Adult rat hepatocytes were isolated from normal livers by two-step in situ collagenase perfusion to facilitate disaggre...