IP Receptor Agonist-Induced DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes: the Involvement of Endogenous Transforming Growth Factor-α

• Auteurs principaux: Mitsutoshi Kimura (Auteur), Hiroshi Okamoto (Auteur), Hideshi Natsume (Auteur), Masahiko Ogihara (Auteur)
• Format: Livre
• Publié: Elsevier, 2009-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

To elucidate the mechanism of action of prostaglandin I2 (PGI2) and carbaprostacyclin, we studied their effect on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Hepatocyte parenchymal cells, maintained in a serum-free, defined medium, synthesized DNA and proliferated i...