Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells

• Main Authors: Duc-Hiep Bach (Author), Donghwa Kim (Author), Song Yi Bae (Author), Won Kyung Kim (Author), Ji-Young Hong (Author), Hye-Jung Lee (Author), Nirmal Rajasekaran (Author), Soonbum Kwon (Author), Yanhua Fan (Author), Thi- (Author), Young Kee Shin (Author), Jeeyeon Lee (Author), Sang Kook Lee (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used clinically as target therapies for lung cancer patients, but the occurrence of acquired drug resistance limits their efficacy. Nicotinamide N-methyltransferase (NNMT), a cancer-associated metabolic enzyme, is commonly o...