A Novel Modulator of the Renin-Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation

• المؤلفون الرئيسيون: Qi-Qiang Zhang (مؤلف), Feng-Hua Chen (مؤلف), Fei Wang (مؤلف), Xue-Mei Di (مؤلف), Wei Li (مؤلف), Hai Zhang (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The monoester alkaloids in Aconitum carmichaelii, including benzoylaconitine (BAC), benzoylmesaconine, and benzoylhypaconitine, were found to have anti-hypertensive effects in spontaneously hypertension rats (SHRs), of which BAC is the strongest. However, its antihypertensive target and underlying m...