A Novel Modulator of the Renin-Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation

• Päätekijät: Qi-Qiang Zhang (Tekijä), Feng-Hua Chen (Tekijä), Fei Wang (Tekijä), Xue-Mei Di (Tekijä), Wei Li (Tekijä), Hai Zhang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The monoester alkaloids in Aconitum carmichaelii, including benzoylaconitine (BAC), benzoylmesaconine, and benzoylhypaconitine, were found to have anti-hypertensive effects in spontaneously hypertension rats (SHRs), of which BAC is the strongest. However, its antihypertensive target and underlying m...