Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A

• Main Authors: Hikaru Koga (Author), Takashi Yamano (Author), Juan Betancur (Author), Satoko Nagatomo (Author), Yousuke Ikeda (Author), Kazuki Yamaguchi (Author), Yoshiaki Nabuchi (Author), Kazuki Sato (Author), Yuri Teranishi-Ikawa (Author), Motohiko Sato (Author), Hiroyuki Hirayama (Author), Akira Hayasaka (Author), Takuya Torizawa (Author), Kenta Haraya (Author), Zenjiro Sampei (Author), Hirotake Shiraiwa (Author), Takehisa Kitazawa (Author), Tomoyuki Igawa (Author), Taichi Kuramochi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTEfficient production of bispecific antibodies (BsAbs) in single mammalian cells is essential for basic research and industrial manufacturing. However, preventing unwanted pairing of heavy chains (HCs) and light chains (LCs) is a challenging task. To address this, we created an engineering te...