Identifying non-nucleoside inhibitors of RNA-dependent RNA-polymerase of SARS-CoV-2 through per-residue energy decomposition-based pharmacophore modeling, molecular docking, and molecular dynamics simulation

• Main Authors: Shahkaar Aziz (Author), Muhammad Waqas (Author), Tapan Kumar Mohanta (Author), Sobia Ahsan Halim (Author), Aqib Iqbal (Author), Amjad Ali (Author), Asaad Khalid (Author), Ashraf N. Abdalla (Author), Ajmal Khan (Author), Ahmed Al-Harrasi (Author)
• Format: Knjiga
• Izdano: Elsevier, 2023-04-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Background and Objective: The current coronavirus disease-2019 (COVID-19) pandemic has triggered a worldwide health and economic crisis. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the disease and completes its life cycle using the RNA-dependent RNA-polymerase (RdRp) enzy...