Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts

• Main Authors: Shoya Ino (Author), Toshiyuki Yano (Author), Atsushi Kuno (Author), Masaya Tanno (Author), Hidemichi Kouzu (Author), Tatsuya Sato (Author), Tomohisa Yamashita (Author), Wataru Ohwada (Author), Arata Osanami (Author), Toshifumi Ogawa (Author), Yuki Toda (Author), Masaki Shimizu (Author), Tetsuji Miura (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence suggests that necroptosis of cardiomyocytes contributes to cardiovascular diseases. Lethal disruption of the plasma membrane in necroptosis is induced by oligomers of mixed lineage kinase domain-like (MLKL) that is translocated to the membrane from the cytosol. However, the rol...