Agomelatine, a Melatonin-Derived Drug, as a New Strategy for the Treatment of Colorectal Cancer

• Main Authors: Sara Moreno-SanJuan (Author), Jose D. Puentes-Pardo (Author), Jorge Casado (Author), Julia Escudero-Feliu (Author), Huda Khaldy (Author), Javier Arnedo (Author), Ángel Carazo (Author), Josefa León (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The potential use of agomelatine as an alternative treatment for colorectal cancer is evaluated in this work. The effect of agomelatine was studied in an in vitro model using two cell lines with different p53 statuses (HCT-116, wild-type p53, and HCT-116 p53 null) and an in vivo xenograft model. The...