Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis

• Main Authors: Patrick D. Olson (Author), Lisa K. McLellan (Author), Alice Liu (Author), Kelleigh L. Briden (Author), Kristin M. Tiemann (Author), Allyssa L. Daugherty (Author), Keith A. Hruska (Author), David A. Hunstad (Author)
• Format: Book
• Published: The Company of Biologists, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We present a new preclinical model to study treatment, resolution and sequelae of severe ascending pyelonephritis. Urinary tract infection (UTI), primarily caused by uropathogenic Escherichia coli (UPEC), is a common disease in children. Severe pyelonephritis is the primary cause of acquired renal s...