Inhibition of cAMP-activated intestinal chloride secretion by diclofenac: cellular mechanism and potential application in cholera.

• Main Authors: Pawin Pongkorpsakol (Author), Nutthapoom Pathomthongtaweechai (Author), Potjanee Srimanote (Author), Sunhapas Soodvilai (Author), Varanuj Chatsudthipong (Author), Chatchai Muanprasat (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclic AMP-activated intestinal Cl- secretion plays an important role in pathogenesis of cholera. This study aimed to investigate the effect of diclofenac on cAMP-activated Cl- secretion, its underlying mechanisms, and possible application in the treatment of cholera. Diclofenac inhibited cAMP-activ...