Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

• Main Authors: Gan Wang (Author), Min Zhang (Author), Ping Meng (Author), Chengbo Long (Author), Xiaodong Luo (Author), Xingwei Yang (Author), Yunfei Wang (Author), Zhiye Zhang (Author), James Mwangi (Author), Peter Muiruri Kamau (Author), Zhi Dai (Author), Zunfu Ke (Author), Yi Zhang (Author), Wenlin Chen (Author), Xudong Zhao (Author), Fei Ge (Author), Qiumin Lv (Author), Mingqiang Rong (Author), Dongsheng Li (Author), Yang Jin (Author), Xia Sheng (Author), Ren Lai (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex (TRiC) contains eight para...