Biomarker and pharmacodynamic activity of the transforming growth factor‐beta (TGFβ) inhibitor SAR439459 as monotherapy and in combination with cemiplimab in a phase I clinical study in patients with advanced solid tumors
Abstract SAR439459, a 'second‐generation' human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody, inhibits all TGFβ isoforms and improves the antitumor activity of anti‐programmed cell death protein‐1 therapeutics. This study reports the pharmacodynamics (PD) and biomarker r...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Book |
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Wiley,
2024-02-01T00:00:00Z.
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Internet
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A1234.567 |
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Copy 1 | Available |