Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

Chondrocyte dysfunction is a key mechanism underlying osteoarthritis. Metformin has shown protective effects in many diseases. The present study aimed to investigate the effects of metformin on autophagy and apoptosis in the process of osteoarthritis. A mouse osteoarthritis model was set up by surgi...

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Main Authors: Chenzhong Wang (Author), Zhenjun Yao (Author), Yueqi Zhang (Author), Yi Yang (Author), Jinyu Liu (Author), Yi Shi (Author), Chi Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
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