Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

• Asıl Yazarlar: Chenzhong Wang (Yazar), Zhenjun Yao (Yazar), Yueqi Zhang (Yazar), Yi Yang (Yazar), Jinyu Liu (Yazar), Yi Shi (Yazar), Chi Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Chondrocyte dysfunction is a key mechanism underlying osteoarthritis. Metformin has shown protective effects in many diseases. The present study aimed to investigate the effects of metformin on autophagy and apoptosis in the process of osteoarthritis. A mouse osteoarthritis model was set up by surgi...