Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe

• Main Authors: Zahi Abu Ghosh (Author), Shoshana Alamia (Author), Chanan Shaul (Author), Yoseph Caraco (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The pharmacokinetics of CYP2C9 substrates is characterized by substantial interethnic variability. The objective of the study was to compare CYP2C9 activity by using Phenytoin Metabolic Ratio (PMR) between Ethiopian and non-Ethiopian Jews. PMR was derived from the ratio of p-HPPH in 24 h urine colle...