Cytokine profiles in early rejection following OKT3 treatment in liver transplant patients

• Main Authors: Sasan Roayaie (Author), Patricia A. Sheiner (Author), Sukru Emre (Author), Steven Guy (Author), Myron E. Schwartz (Author), Peter Boros (Author), Charles M. Miller (Author)
• Format: Book
• Published: Hindawi Limited, 2000-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OKT3, a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFα and IL1β. Liver recipients who experience rejection within 3 weeks after transplan...