The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

• Main Authors: Yu-Liang Jiang (Author), Zi-Ye Zhao (Author), Bai-Rong Li (Author), Fu Yang (Author), Jing Li (Author), Xiao-Wei Jin (Author), Hao Wang (Author), En-Da Yu (Author), Shu-Han Sun (Author), Shou-Bin Ning (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Peutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway. Methods PJS probands with STK11 mutation were included in the function analysis. P53 activity elevated by STK11 mutants was...