Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs

Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs

Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from its pan-JAKs inhibition and ubiquitous biodist...

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Main Authors: Viola Previtali (Author), Ulrik Bering Keiding (Author), Asger Hegelund Olsen (Author), Jorge Peiró Cadahía (Author), Anne Skovsbo Clausen (Author), Andreas Kjaer (Author), Thomas Lars Andresen (Author), Anders Elias Hansen (Author), Mads Hartvig Clausen (Author)
Format: Book
Published: Elsevier, 2022-04-01T00:00:00Z.
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