Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration

• Main Authors: Thibaut Desgeorges (Author), Eva Galle (Author), Jing Zhang (Author), Ferdinand von Meyenn (Author), Katrien De Bock (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macrophage polarisation. Here, we explore the in vivo rele...