S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

• Main Authors: Indira Mendez-David (Author), Jean-Philippe Guilloux (Author), Mariusz Papp (Author), Laurent Tritschler (Author), Elisabeth Mocaer (Author), Alain M. Gardier (Author), Sylvie Bretin (Author), Denis J. David (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutamatergic dysfunctions are observed in the pathophysiology of depression. The glutamatergic synapse as well as the AMPA receptor's (AMPAR) activation may represent new potential targets for therapeutic intervention in the context of major depressive disorders. S 47445 is a novel AMPARs posi...