Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms

• Main Authors: Robin E. Walsh (Author), Megan Lannan (Author), Yi Wen (Author), Xiaoli Wang (Author), Christopher A. Moreland (Author), Jill Willency (Author), Michael D. Knierman (Author), Laura Spindler (Author), Ling Liu (Author), Wei Zeng (Author), Guilherme V. Rocha (Author), Victor Obungu (Author), Jirong Lu (Author), Arunan Kaliyaperumal (Author), Andrea Ferrante (Author), Robert Siegel (Author), Laurent P. Malherbe (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biologics have the potential to induce an immune response when used therapeutically. A number of in vitro assays are currently used preclinically to predict the risk of immunogenicity, but the validation of these preclinical tools suffers from the relatively small number of accessible immunogenic mo...